Title : Spectroscopic investigation and vibrational assignments on life saving pharmceutical compounds
Abstract:
There is general possible way to determine the standard regimen of drug which will have reasonable effect and will be provided based on the age and weight of the administered. Most drugs act by combining specific receptors acted on the cells within the larger tissue. Only a very small portion of the total drug reaches the receptor. The remaining portions are lost by the processes of absorption, distribution and elimination. These processes determine the concentration of the drug in the given tissue at any particular time administration. Pharmaco-dynamics applies to the study of those aspects of drug behavior which relate to its actions or effect. The term Pharmaco-kinetics applies to the study of the factors that determine its effective concentration at the site of action. According to Pharmaco-kinetics, the variability of response to drugs it due to the differences in the blood and tissue concentrations from one person to another. Many drugs fall into one to two broad categories, chemotherapeutic and compound action on the central nervous system. Chemotherapeutic agent is a substance that inhibits or destroys a infectious organism such as pathogenic bacteria or parasites which have invaded the host. Antibiotics are chemotherapeutic agent that are produced by micro- organisms and are toxic to other organisms, particularly bacteria and viruses. Tetracycline and ampicillin are the major drugs and since they become available in 1945 it has saved thousands of human lives from fatal bacillary infection like plague. Tetracyclines are characterized by their exceptional chemotherapeutic efficacy against a wide range of Gram Positive and Gram negative bacteria, rickettsia, spirochetes and large viruses, such as members of the lymphogranuloma group. Tetracycline inhibits a lot of enzyme reactions essential for vital processes of bacterial cells. The most sensitive biochemical reaction that is inhibited is the synthesis of proteins. Tetracycline works by binding specifically to the 30S ribosome of the bacteria, preventing attachment of the aminacyl tRNA to the RNA ribosome complex. It simultaneously inhibits other steps of the protein biosynthesis. Tetracycline can also alter the cytoplasmic membrane and this in turn causes leakage of nucleotides and other compounds out of the cell. This does not directly kill bacteria but instead inhibit.
