HYBRID EVENT: You can participate in person at Paris, France or Virtually from your home or work.
Joana Filomena Campos, Speaker at Catalysis Conferences
Université d’Orléans, France
Title : “Bio-based solvent”: New solvent for the synthesis of heterocycles containing oxygen, sulfur and nitrogen


The search for alternatives with less environmental impact and the study focused on the selection of solvents used in the chemical laboratories has been increasing in recent years. There are already several articles that have been reporting bio-based solvents as effective alternatives to conventional solvents derived from petroleum for the synthesis of O, S, N-Heterocyclic compounds. Continuing the field of our team with a view to the development of new methodologies and greener approaches in the synthesis of heterocycles containing oxygen, sulfur and nitrogen, we explored the potentialities of a new solvent. The synthesis process started by the identification of two unusual solvents and later the study of its application in several reactions to show the potential and efficacy as a greener alternative in the synthesis of O, S, N-Heterocyclic compounds via some Pd-catalysed methodologies. Pd catalysed processes have become an approach of choice in modern organic synthesis. In this work, we described the successfully application of a “new bio-based solvent” in several Pd-catalysed methodologies (CH activation, Suzuki-Miyaura coupling, SonogashiraHagihara coupling and Migita Kosugi Stille coupling). It was showed the potential and efficacy as a greener alternative in the synthesis of O, S, N-Heterocyclic compounds. As our article is in the submission process, the name of the bio-based solvent was not mentioned yet.

Audience Take Away:

The use of greener routes are well-appreciated approaches in the fields of green chemistry and synthesis of N-heterocyclic, due to the remarkable importance that these compounds represent in the area of medicinal chemistry. Solvents play an important role in the chemical industry and their effectiveness in acting with the reagents and products in reaction processes is a crucial factor. The choice of solvent is going to influence chemical reactivity, selectivity and yield of the process of synthesis. One way to try to minimize safety, toxicity, and emissions problems is to find or develop replacement solvents commonly used. In recent years, valid proposals have been reported as green solvents used in the synthetic processes. With all this results in the search for safer solvents, the concepts of green chemistry have achieved remarkable progress in developing greener approaches in organic synthesis. We believe this oral presentation will provide information to further advance the applications of “bio-based solvent” in Pd-catalysed methodologies. Additionally, the sharing and discussion of this work would be helpful to a broad community of scientists working in medicinal chemistry. 


Joana Filomena Campos, born in Trofa, Portugal, in 1989. She completed her BSc degree (Pharmacy) in 2011 from CESPU, and MSc degree (Medicinal Chemistry) in 2013 from the University of Minho. Currently, she is in 3rd and last year of PhD at the Institut of Organic and Analytical Chemistry (ICOA) of the University of Orléans (France) under the supervision of Professor Sabine Berteina-Raboin. Her research interests focus on the study of new and greener approaches for the synthesis of O,S,N-heterocyclic compounds. Since the beginning of her PhD, she has published with her team 6 articles and others are in preparation for submission soon.