HYBRID EVENT: You can participate in person at Paris, France or Virtually from your home or work.
Michael G Kallitsakis, Speaker at Catalysis Conferences
Aristotle University of Thessaloniki, Greece
Title : Copper-benzotriazole based coordination polymer as catalyst towards the onepot synthesis of N’-substituted-hydrazo-1,4-dihydropyridines


1,4-dihydropyridines (1,4-DHPs) represent one of the most important class of N-containing heterocyclic compounds, used as L-type calcium channel blockers in the treatment of cardiovascular diseases. Therefore, useful synthetic strategies for 1,4-dihydropyridines have been developed. Recently, much attention has been directed toward the synthesis of N-substituted-1,4-dihydropyridines with interesting biological properties. In this respect, we elaborate the efficient one-pot synthesis of novel symmetrical (Ν’-substituted)-hydrazo-4-aryl-1,4-dihydropyridines in moderate to good yields from electron-rich azines and propiolate esters catalyzed by a one-dimensional copper-benzotriazole based coordination polymer. The reaction proceeds with low catalyst loading, under mild catalytic conditions and without the need of inert atmosphere and base additives. Fine-tuning the catalyst allowed us to gain more insights regarding the plausible reaction mechanism.

Audience Take Away:

  • Metal-catalyzed organic synthetic methodology.
  • Homogeneous catalysis in the area of Green Chemistry.
  • Cu(II)-benzotriazole based one-dimensional coordination polymers chemistry.
  • Synthesis of (Ν’-substituted)-hydrazo-4-aryl-1,4-dihydropyridines as molecules with biological activity.


Dr. Kallitsakis, received his Bachelor (2007) at the Chemistry Department of the Aristotle University of Thessaloniki, and he earned his Master’s Degree (2009) and his PhD at the same institution (2014) under the supervision of Prof. Litinas. Since 2015, he is working as a post-doctoral researcher under the supervision of Prof. Armatas and Prof. Lykakis, with an ERC grand and IKY fellowship. During his post-doctoral period (2016) he worked as a visiting Researcher at the School of Life Sciences of University of Sussex in collaboration with Assoc. Prof. G. Kostakis. So far, he has 12 publications in peer reviewed journals.