Title : Copper-benzotriazole based coordination polymer as catalyst towards the onepot synthesis of N’-substituted-hydrazo-1,4-dihydropyridines
Abstract:
1,4-dihydropyridines (1,4-DHPs) represent one of the most important class of N-containing heterocyclic compounds, used as L-type calcium channel blockers in the treatment of cardiovascular diseases. Therefore, useful synthetic strategies for 1,4-dihydropyridines have been developed. Recently, much attention has been directed toward the synthesis of N-substituted-1,4-dihydropyridines with interesting biological properties. In this respect, we elaborate the efficient one-pot synthesis of novel symmetrical (Ν’-substituted)-hydrazo-4-aryl-1,4-dihydropyridines in moderate to good yields from electron-rich azines and propiolate esters catalyzed by a one-dimensional copper-benzotriazole based coordination polymer. The reaction proceeds with low catalyst loading, under mild catalytic conditions and without the need of inert atmosphere and base additives. Fine-tuning the catalyst allowed us to gain more insights regarding the plausible reaction mechanism.
Audience Take Away:
- Metal-catalyzed organic synthetic methodology.
- Homogeneous catalysis in the area of Green Chemistry.
- Cu(II)-benzotriazole based one-dimensional coordination polymers chemistry.
- Synthesis of (Ν’-substituted)-hydrazo-4-aryl-1,4-dihydropyridines as molecules with biological activity.
