Enantioselective [4 + 2]-annulation of oxadienes and allenones catalyzed by an amino acid derived phosphine: Synthesis of functionalized dihydropyrans

Title : Enantioselective [4 + 2]-annulation of oxadienes and allenones catalyzed by an amino acid derived phosphine: Synthesis of functionalized dihydropyrans

Abstract:

An enantioselective [4 + 2]-annulation process between cyano-activated oxadienes and allenones is developed. An L-valine-derived phosphine was efficient in catalyzing the reaction, and a wide range of highly functionalized dihydropyrans were prepared in high yields and with excellent enantioselectivities.

Audience Take Away:

• Oxadienes is used as a C4 synthon, in combination with allene ketones to produce structurally unique ring motifs.
• A wide range of highly functionalized dihydropyrans can be synthesized by adopting to our synthesis method.
• The audience would realize a new methodology of constructing synthetically useful molecular architectures.

Biography:

Prof. Nisar obtained his PhD from the University of Graz, in 2001. He then assumed postdoctoral positions in McMaster University and University of Guelph, Canada, for one year each. He joined KFUPM as an Assistant Professor in 2007 where he is now a Professor of Organic Chemistry. His research is mainly centered on the organic synthesis, designed based drug development and environmental chemistry. He has authored more than 85 papers in reputed journals and is the recipient of Diligence, Dedication and Performance Award by Pfizer Ann Arbor, USA in 2005 and Excellence in Research Award, KFUPM, in the year 2019.