Title : Enantioselective [4 + 2]-annulation of oxadienes and allenones catalyzed by an amino acid derived phosphine: Synthesis of functionalized dihydropyrans
An enantioselective [4 + 2]-annulation process between cyano-activated oxadienes and allenones is developed. An L-valine-derived phosphine was efficient in catalyzing the reaction, and a wide range of highly functionalized dihydropyrans were prepared in high yields and with excellent enantioselectivities.
Audience Take Away:
- Oxadienes is used as a C4 synthon, in combination with allene ketones to produce structurally unique ring motifs.
- A wide range of highly functionalized dihydropyrans can be synthesized by adopting to our synthesis method.
- The audience would realize a new methodology of constructing synthetically useful molecular architectures.