Studies towards at the synthesis of (+)-Adenophorine

Title : Studies towards at the synthesis of (+)-Adenophorine

Abstract:

Iminosugars are frequently synthesized from carbohydrates as chiral pool starting materials with use of an amination–intermolecular cyclization sequence or an intramolecular reductive amination cyclization anas the key step. The asymmetric total synthesis of (+)-adenophorine a rare example of a naturally occurring iminosugar bearing a lipophilic substituent at the anomeric position. The absolute configuration of this (+)-iminosugar, isolated from Adenophora spp. by Ikeda and co-workers in 2000, was determined three years later by optical rotation measurements performed on the (–) enantiomer synthesized by Davis et ali . In our strategy, the configuration of each stereogenic center has to be controlled during the building steps. We wish to construct applying key reactions as reductive amination and organocatalytic reaction.

Audience Takeway: 

• The public will be able to learn the experimental part, which is one of the main challenges of this work
• With this investigation in a similar way we will be able to prepare new chemical compounds
• The methodology used allows its extension to the teaching component
• Organocatalysis has numerous advantages.

Biography:

Dr. Maria Candeia Kuliakita Sakukuma studied Chemistry at the Higher Institute of Education Sciences, Department of Exact Sciences, 230, Isced-Huíla, Lubango, Angola and graduated. She then joined the research group of Prof. Maurício Victor at Chemistry Institute, Federal University of Bahia, UFBA, in 2014, when received her MS and PhD degree in 2017 at the same institution. After one year postdoctoral fellowship supervised by Dr Steve Davies working about in Synthetic Methodolgy with Lithium Amide Conjugate Addition and Total Synthesis at the University of Oxford, UK she obtained the position of an Auxiliar Professor where work actually.