C-C bond formation

Over the past 10 years, there has been rapid advancement in the production of C-C bonds by carbometallation, particularly in reactions that are promoted by group 8–11 metals. It is now possible to securely design inter- and intramolecular processes, as well as sequences that combine the two, to produce useful substrates like carbo- and heterocycles. It was discovered that when imidazole was deprotonated with potassium t-butoxide in liquid ammonia via electrochemically induced SRN1, direct C-C bond formation at the 2-position of imidazole and benzimidazole occurred. Over the past 10 years, there has been rapid advancement in the production of C-C bonds by carbometallation, particularly in reactions that are promoted by group 8–11 metals. It is now possible to securely design inter- and intramolecular processes, as well as sequences that combine the two, to produce useful substrates like carbo- and heterocycles.