By adjusting the concentrations of ligands—non-scaffold molecules that bind to particular sites on scaffolds—phase transitions of scaffolds can be controlled. The valence of ligands, whether or not they bind directly to stickers or spacers, and the relative affinities of ligand-scaffold versus scaffold-scaffold interactions determine the modulatory effects of ligands. The concentration of scaffolds in condensates is typically diluted by all ligands. Multivalent ligands can stabilise condensates by binding directly to spacers or destabilise condensates by binding directly to stickers, in contrast to monovalent ligands, which destabilise condensates. Even when they have no effect on condensate stability, bipartite ligands that bind to stickers and spacers can change the structural arrangement of scaffold molecules there.
Ephraim Suhir
Portland State University, United States
Thomas J J Muller
Heinrich-Heine-Universitat Dusseldorf, Germany
Stanislaw Dzwigaj
Sorbonne University, France
Dai Yeun Jeong
Jeju National University, Korea, Republic of
Ephraim Suhir
Portland State University, United States
Marta I Litter
University of General San Martin, Argentina
Abdeltif Amrane
Institute of Chemical Sciences of Rennes, France
Mikhail Kashchenko
Ural'skiy Gosudarstvennyy Lesotekhnicheskiy Universitet, Russian FederationSubmit your abstract Today
Title : Personalized and Precision Medicine (PPM) as a unique healthcare model via design-driven bio- and chemical engineering view of biotech
Sergey Suchkov, R&D Director of the National Center for Human Photosynthesis, Mexico
Title : Catalytic one-pot multicomponent syntheses of functional chromophores – Synthetic efficiency meets functionality design
Thomas J J Muller, Heinrich-Heine-Universitat Dusseldorf, Germany
Title : Use of iron nanomaterials for the treatment of metals, metalloids and emergent contaminants in water
Marta I Litter, University of General San Martin, Argentina
Title : The roles and capacity building of NGOs as agents responding to climate change
Dai Yeun Jeong, Jeju National University, Korea, Republic of
Title : Application of metal single-site zeolite catalysts in heterogeneous catalysis
Stanislaw Dzwigaj, Sorbonne University, France
Title : From photocatalysis to photon-phonon co-driven catalysis for inert molecules activation
Junwang Tang, Tsinghua University, China