By adjusting the concentrations of ligands—non-scaffold molecules that bind to particular sites on scaffolds—phase transitions of scaffolds can be controlled. The valence of ligands, whether or not they bind directly to stickers or spacers, and the relative affinities of ligand-scaffold versus scaffold-scaffold interactions determine the modulatory effects of ligands. The concentration of scaffolds in condensates is typically diluted by all ligands. Multivalent ligands can stabilise condensates by binding directly to spacers or destabilise condensates by binding directly to stickers, in contrast to monovalent ligands, which destabilise condensates. Even when they have no effect on condensate stability, bipartite ligands that bind to stickers and spacers can change the structural arrangement of scaffold molecules there.
Stanislaw Dzwigaj
Sorbonne University, France
Dai Yeun Jeong
Asia Climate Change Education Center and Jeju National University, Korea, Republic of
Samy Ponnusamy
MilliporeSigma, United States
Title : Techniques for carbon dioxide sequestration and the way forward
Collin G Joseph, University Malaysia Sabah, Malaysia
Title : Application of vanadium and tantalum single-site zeolite catalysts in heterogeneous catalysis
Stanislaw Dzwigaj, Sorbonne University, France
Title : Indicators for evaluating green management practice of enterprises
Dai Yeun Jeong, Asia Climate Change Education Center and Jeju National University, Korea, Republic of
Title : DOZN™3.0 - A quantitative green chemistry evaluator for a sustainable future
Samy Ponnusamy, MilliporeSigma, United States
Title : Towards integrated biodesign-inspired translational platforms to co-develop innovative biotechnologies, biomanufacturing and biomarket-ing to revolutionize the future of the personalized & precision healthcare and life science bioindustry
Sergey Victorovich Suchkov, N.D. Zelinskii Institute for Organic Chemistry of the Russian Academy of Sciences, Russian Federation