In order to increase the efficiency of a chemical reaction, one-pot synthesis involves putting a reactant through multiple chemical reactions in a single reactor. Chemists are very interested in this because it can reduce the need for time-consuming separation procedures and chemical compound purification while also boosting chemical yield. Tropinone's total synthesis or the Gassman indole synthesis are two examples of one-pot synthesises. Sequential one-pot syntheses can be used to produce even complex targets with multiple stereocenters, like oseltamivir, potentially reducing the overall number of steps and having significant commercial implications. Also known as a telescoping synthesis, a sequential one-pot synthesis involves adding reagents to a reactor one at a time without work-up.
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Vladislav Sadykov, Novosibirsk State University, Russian Federation
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Rawia Nasri, University of Tunis El Manar, Tunisia
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Yuxiang Zhu, Yunnan University, China