The unsaturated coordination configuration of the active centres, the quantum size effect, and the support effect, which bridge the gap between homogeneous and heterogeneous catalysis, are the causes of the extraordinary catalytic activity and selectivity of single-site catalysts (SSCs), which are emerging as a new class of catalysts. The most efficient way to use precious metals is through the SSCs, which are extremely appealing. The SSCs have so far displayed good catalytic activity in a number of critical processes, including the oxidation/hydrogenation reaction, water-gas shift, and electrocatalysis3,5. The majority of synthetic procedures need specialised tools, laborious processes, or pricey precursors, and SSCs frequently aggregate throughout the catalytic procedure. Metal-support interactions, a fundamental factor in SSC investigations, play a significant role in the creation and catalytic durability of SSCs.