Indirect drug design is another name for it. It is predicated on knowledge of several novel ligand compounds that bind to the target protein molecule. These variously created molecules are employed to create a fresh explanation for each and every component involved in the interaction between the ligand and the target protein molecule. These components should improve the interaction between a ligand and a protein if they are present in a ligand. Additionally, a target protein model based on the composite ligand is created. Drug design based on ligands is influenced by the knowledge of other compounds that bind to the biological target's active site out of interest. These kinds of compounds are utilised to create a model that accurately captures the crucial structural characteristics of a lead molecule. Using the knowledge of the molecules that bind, a biologically active target model is created. The development of new compounds that interact with the biologically active target molecule is guided by this model. The term "quantitative structure activity relationship" refers to a relationship that was found between the biological activity of a molecule as determined through experiment and its calculated properties. Predictions about the new molecules' activity are made using QSAR studies. Protein models are typically created to gather ever-increasing amounts of data regarding the various ligands and how they interact with the target protein. The protein molecule should act as an enzyme, which is a key target for rational drug design. By converting the energy level from the substrate molecule into product formation, enzymes are the molecules that catalyse biochemical reactions.